Allergology: Introduction and Physiopathological Bases of Allergic Diseases

Allergology and Immunology · Clinical Specialties

How it begins

A scientific compendium and detailed medical reference, aimed at specialists in allergology, immunology and related medical disciplines. It rigorously addresses cellular ontogeny, molecular signaling cascades, the genetics of atopy, hypersensitivity mechanisms, epithelial barrier theory, and advanced biological therapeutics.

What it covers

1. Ontogeny of the Allergic Immune System and Epithelial Barriers
2. Presentation of Antigens, Dendritic Cells and Immune Synapses
3. T Helper Lymphocytes and Their Phenotypic Plasticity
4. B Lymphocytes, Isotype Change and Regulation of IgE Synthesis
5. The High Affinity Receptor (FcεRI) and Low Affinity Receptor (FcεRII/CD23)
6. · High Affinity Receptor for IgE (FcεRI)
7. · Low Affinity Receptor for IgE (FcεRII / CD23)
8. Mast Cells and Basophils: Ontogeny, Receptors and Non-IgE Activation
9. · Non-IgE Activation Mediated by the MRGPRX2 Receptor
10. Eosinophils: Cell Biology and Cationic Granulation Proteins
11. · Cationic Proteins of Secondary Granules
12. Histamine and its Receptors (H1, H2, H3, H4)
13. Lipid Mediators of De Novo Synthesis
14. · The 5-Lipoxygenase Pathway: Cystenyl Leukotrienes (CysLTs)
15. · The Cycloxygenase Pathway: Prostaglandin D2 (PGD2)
16. Chemokines, Key Cytokines and Epithelial Alarmins
17. · The Type 2 Cytokine Trio
18. · Epithelial Alarmins and Type 2 Innate Lymphoid Cells (ILC2)
19. Gell and Coombs Classification Revisited
20. Type I Hypersensitivity (Immediate)
21. · 1. Sensitization Phase (Asymptomatic)
22. · 2. Early Effector Phase (Minutes)
23. · 3. Late Effector Phase (4 to 24 Hours)
24. Type II and Type III Hypersensitivity in the Context of Allergology
25. · Type II Mechanism (Blood Cell Haptenization)
26. · Type III Mechanism (Serum Sickness and Vasculitis)
27. Type IV Hypersensitivity: Subtypes and Complex Skin Reactions
28. · Pathophysiology of Severe Cutaneous Adverse Drug Reactions (SCARs)
29. Physicochemistry of Allergens and Cross Reactivity
30. Respiratory Allergens (Pneumoallergens)
31. · 1. House Dust Mites (*Dermatophagoides pteronyssinus* and *D. farinae*)
32. · 2. Pollens (Grasses, Trees and Weeds)
33. · 3. Domestic Animal Epithelia
34. Food Allergens (Trophoallergens)
35. · Oral Allergy Syndrome (OSS)
36. Occupational Allergens, Hymenoptera Venoms and Chemical Haptens
37. · Hymenoptera Poisons (Bees and Wasps)
38. · Chemical Haptens and Contact Immunity
39. Atopy Genomics: Susceptibility Loci
40. Epigenetics in Allergy: DNA Methylation and Histones
41. The Hygiene Hypothesis Revisited and the Microbiome Theory
42. Bronchial Asthma: Phenotypes, Endotypes and Airway Remodeling
43. · T2-High Endotype (Eosinophilic / Type 2)
44. · T2-Low Endotype (Neutrophilic or Paucigranulocytic)
45. Allergic Rhinitis and Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)
46. Atopic Dermatitis: Filaggrin Dysfunction, Barrier and Neurogenic Inflammation
47. · Genetic Barrier Dysfunction: The Filaggrin Gene (*FLG*)
48. · Colonization and Pathogenic Role of *Staphylococcus aureus*
49. · The Pruritus and Neurogenic Inflammation Pathway
50. Food Allergies and Immuno-Gastroenterology: From Anaphylaxis to Eosinophilic Esophagitis
51. · Systemic Mediated IgE Reactions
52. · Non-IgE Mediated Reactions: Food Protein Induced Enterocolitis Syndrome (FPIES)
53. · Eosinophilic Esophagitis (EoE)
54. Systemic Anaphylaxis: Pathophysiology of Anaphylactic Shock
55. · Hepatophysiology of Hemodynamic Changes in Shock
56. Molecular Component Diagnosis (CRD) and In Vitro Functional Tests
57. · Clinical Advantages of Molecular Diagnosis
58. · The Basophil Activation Test (BAT)
59. Allergen Immunotherapy (ITA): Immunological Tolerance Mechanisms
60. Immunobiologicals and Precision Therapies in Complex Allergic Pathologies
61. · Omalizumab (Anti-IgE)
62. · Dupilumab (Anti-IL4Rα)
63. · Antibodies Directed against the Eosinophil Axis
64. · Tezepelumab (Anti-TSLP)
65. Intervention Algorithm in Severe Asthma and Type 2 Pathologies