Clinical Biochemistry — Cancer and Molecular Pathology

Biochemistry · Basic Sciences

How it begins

An exhaustive compendium at the level of medical specialization on the molecular bases of cancer. Addresses oncogenic signaling, metabolic and immunological remodeling, advanced characterization of serum and genetic biomarkers, and analytical challenges in the clinical laboratory.

What it covers

1. Introduction to Oncological Biochemistry and Hallmarks
2. · The Hallmarks of Cancer and its Molecular Mediators
3. · Main Oncological Signal Transduction Pathways
4. Tumor Metabolism and the Warburg Effect
5. · Comparison of the Performance and Flow of Metabolic Carbons
6. · Enzymatic Mechanisms of Aerobic Glycolysis
7. · Glutaminolysis: The alternative nitrogen fuel
8. Classical Serum and Tissue Biomarkers
9. · Detailed Biochemical Analysis of Classic Tumor Biomarkers
10. Precision Genetic and Epigenetic Markers
11. · Main Genomic Alterations and Their Therapeutic Implication
12. · Tumor Mutational Burden (TMB): The Neoantigen Metric
13. Clinical Oncology Enzymology
14. · Main Enzymes of Clinical Use in Oncology
15. Oncological Proteomics and Metabolomics
16. Biochemistry of Invasion and Metastasis
17. · The Cascade of Invasion and Metastasis
18. Tumor Immunology and Microenvironment
19. · Biochemistry of Immune Checkpoints
20. · The Immunosuppressive Tumor Microenvironment (ITM)
21. Paraneoplastic Endocrine-Metabolic Syndromes
22. · Main Endocrinopathies and Paraneoplastic Alterations
23. Pharmacogenomics and Therapeutic Resistance
24. · Genetic Variants and their Clinical Impact on Oncological Treatment
25. Hydroelectrolyte Alterations and Tumor Lysis Syndrome
26. · Pathophysiology of Tumor Lysis Syndrome (TLS)
27. Advanced Liquid Biopsy and cfDNA
28. Analytical Phase, Interferences and Quality Control
29. · Main Analytical Challenges and Interferences
30. Clinical Cases and Laboratory Correlations