Clinical Biochemistry of Infertility: Pathophysiology, Diagnosis and Biomarkers

Biochemistry · Basic Sciences

How it begins

Infertility is a complex disorder with a metabolic, genetic, immunological and endocrine basis. This treatise exhaustively exposes the signaling mechanisms, the biochemical pathways of steroidogenesis, the gametic function and the diagnostic techniques in the assisted reproduction laboratory.

What it covers

1. Endocrinology of the Hypothalamic-Pituitary-Gonad (HHG) Axis
2. Oocyte Biochemistry and Regulation of the Ovarian Reserve
3. · The Theory of Two Cells, Two Gonadotropins
4. Biochemical Physiology of Sperm and Seminal Plasma
5. · Molecular Mechanism of Training
6. Advanced Spermogram and Seminal Biochemical Markers
7. · Biochemical Markers of Accessory Glands
8. · Sperm DNA Fragmentation (SDF)
9. Female Endocrine-Metabolic Dysfunctions: PCOS and Endometriosis
10. · Biochemical Pathophysiology of Endometriosis
11. Male Endocrine Dysfunctions and Hypogonadism
12. · Molecular Defects in Leydigian Steroidogenesis
13. Immunological Factors of Infertility
14. · Antisperm Antibodies (ASA)
15. · Natural Killer (NK) Cells: Peripheral vs. Uterine
16. Pathophysiology of Implantation and Receptive Endometrium
17. Biochemistry of Oxidative Stress and Mitochondrial Dysfunction
18. · Antioxidant Defense Systems in the Reproductive Tract
19. Genetics and Epigenetics of Infertility
20. · Y Chromosome Microdeletions
21. · Mutations in the CFTR Gene and Agenesis of the Vas Deferens
22. Hormonometry and Immunoassays in the Reproduction Laboratory
23. · Hook Effect (Prozone Effect)
24. · Interferences by Heterophile Antibodies and Biotin
25. Ovarian Reserve Tests and Folliculogenesis Dynamics
26. · Anti-Müllerian Hormone (AMH) as a Biomarker
27. · Day 3 Classic Endocrine Evaluation
28. Evaluation of the Recurrent Pregnancy Loss Factor (PGR)
29. · Hereditary Thrombophilias: Molecular Physiopathology
30. Biomarkers in Assisted Reproduction Techniques (ART)
31. · Biochemistry of Follicular Fluid
32. · Non-Invasive Metabolomics of Spent Culture Medium (SCM)
33. Unexplained infertility and Endocrine Disruptors
34. · Bisphenol A (BPA) and its Molecular Effects
35. · Phthalates and Leydig Cell Dysfunction
36. Ovarian Stimulation Protocols and their Biochemical Monitoring
37. · Pituitary Blockade Systems: Agonists vs. Antagonists
38. · Pathophysiology of Ovarian Hyperstimulation Syndrome (OHSS)
39. Advanced Sperm Function Tests
40. · Evaluation of the Acrosome Reaction
41. · Hyaluronic Acid (HBA) Binding Assay
42. Clinical Diagnostic Algorithms and Multidisciplinary Integration
43. · Female Infertility Diagnosis Algorithm
44. · Male Infertility Diagnosis Algorithm