Clinical Biochemistry of Cellular Aging | Molecular Gerontology Treatise

Biochemistry · Basic Sciences

How it begins

In-depth study of the molecular mechanisms of aging, integrating genomic instability, telomere biology, oxidative stress, collapse of proteostasis, epigenetics and extracellular matrix remodeling, with their corresponding correlations of clinical diagnosis and emerging therapeutic targets.

What it covers

1. Cellular Aging
2. The Senescent Phenotype and Genomic Instability
3. · 1.1 · Genomic Stressors and the DNA Damage Response (DDR)
4. · 1.2 · Types of DNA Damage and Specific Repair Pathways
5. · 1.3 · Systemic Consequences of Genomic Instability
6. Telomere Biology and the Shelterina Complex
7. · 2.1 · Structure of Telomeres and the Shelterina Protective Complex
8. · 2.2 · Biochemistry of Telomerase and Ribonucleoprotein Structure
9. · 2.3 · The G-Quadruplex Transition Phenomenon
10. Signaling Pathways for the Stop of the Cellular Cycle
11. · 3.1 · The p53-p21 CIP1 Axis: G1/S Transition Control
12. · 3.2 · Formation of Senescence-Associated Heterochromatin Foci (SAHF)
13. Oxidative Stress and Mitochondrial Insufficiency (Mito-Aging)
14. · 4.1 · Dynamics of Electron Leakage and Production of Free Radicals
15. · 4.2 · Mitochondrial DNA (mtDNA) vulnerability
16. Proteostasis Collapse and Loss of Proteolysis
17. · 5.1 · The Ubiquitin-Proteasome System (UPS) in Aging
18. · 5.2 · Accumulation of Lipofuscin and Advanced Glycation Products (AGEs)
19. The Senescence-Associated Secretory Phenotype (SASP)
20. · 6.1 · Biochemical Architecture of the SASP Components
21. Epigenetic Alterations and Horvath's Clocks
22. · 7.1 · DNA Methylation and Architectural Changes
23. · 7.2 · Biostatistics of Epigenetic Aging Clocks
24. Sensory Nutrient Dysregulation
25. · 8.1 · The Anabolic Nutritional Axis: IIS Signaling and mTOR Complex
26. · 8.2 · The Catabolic Axis of Longevity: AMPK and Sirtuins (NAD + Axis)
27. Stem Cell Exhaustion
28. · 9.1 · Alterations in Key Tissue Niches
29. · 9.2 · Dynamics of Asymmetric Self-Renewal Loss
30. Transposons and the cGAS-STING Pathway
31. · 10.1 · Derepression of Transposons and LINE-1 Elements
32. Lipid Metabolism and Cell Membranes
33. · 11.1 · Biochemistry of Membrane Lipid Peroxidation
34. · 11.2 · Imbalance in the Composition of Lipid Rafts
35. Biochemistry of Extracellular and Interstitial Aging
36. · 12.1 · Collagen Glycation and Maillard Cross-Link Formation
37. · 12.2 · Imbalance in the Activity of Metalloproteinases (MMPs)
38. Immunosenescence and the Inflammaging Phenomenon
39. · 13.1 · Thymic Involution and Remodeling of the T Lymphocyte Repertoire
40. · 13.2 · The Dual Role of Macrophages in Peripheral Senescence
41. Biomarkers of Senescence and Diagnosis
42. · 14.1 · Kinetics and Histochemistry of Senescence-Associated β-Galactosidase (SA-β-gal)
43. · 14.2 · Molecular Markers for Immunohistochemistry and Protein Profiling
44. Accelerated Aging Syndromes
45. · 15.1 · Hutchinson-Gilford Syndrome: The Defect in Nuclear Lamination
46. · 15.2 · Molecular Physiopathology of Werner, Cockayne and Ataxia-Telangiectasia
47. Senolithic and Senomorphic Strategies
48. · 16.1 · Mechanisms of Action of Senolytic Drugs
49. · 16.2 · Pharmacology of Senomorphic Agents
50. · 16.3 · Key Principles in Clinical Biochemistry of Cellular Aging