Cell Cycle and Cancer — Molecular Biology

Molecular Biology · Basic Sciences

How it begins

Comprehensive and technically rigorous analysis of cell cycle regulation, the molecular bases of neoplastic transformation, oncogenic signaling pathways, the tumor microenvironment and therapeutic targets in precision oncology.

What it covers

1. Introduction: The Cell Cycle as the Axis of Molecular Oncology
2. Phases of the Cell Cycle: Temporal Organization
3. · Division of the cycle into phases
4. CDKs, Cyclins and Inhibitors: The Molecular Engine of the Cycle
5. · Cyclin-dependent kinases (CDKs)
6. · CDK inhibitors (CKIs)
7. Cell Cycle Checkpoints
8. · Concept and function of checkpoints
9. The Rb–E2F Pathway: The G1/S Restriction Point
10. · The Rb protein as a master regulator of G1/S
11. p53 — The Guardian of the Genome
12. · Structure and function of p53
13. · P53 regulation: the MDM2–p53 axis
14. Apoptosis: Programmed Cell Death and its Regulation in the Cell Cycle
15. · Apoptosis pathways
16. Cellular Senescence, Quiescence and Mitotic Catastrophe
17. · Senescence as a tumor barrier
18. Cancer Hallmarks — Hanahan Weinberg
19. Oncogenes and Proto-oncogenes
20. · Oncogenic activation mechanisms
21. · Oncogenes of greatest clinical relevance
22. Tumor Suppressor Genes
23. · Classification and inactivation mechanisms
24. Genomic Instability and DNA Repair Pathways in Cancer
25. · The genome as a constant target of damage
26. Epigenetics and Cancer
27. · Epigenetic alterations in neoplastic transformation
28. Panorama of Signaling Pathways in Cancer
29. RAS–MAPK Pathway: Oncogenic Mitogenic Signaling
30. · Molecular cascade of the RAS–MAPK pathway
31. PI3K–AKT–mTOR Pathway: Survival, Metabolism and Growth
32. · The central survival path
33. Wnt–β-catenin Pathway and Colorectal Cancer
34. · Regulation of β-catenin
35. Notch and Hedgehog tracks
36. · Notch
37. · Hedgehog (Hh)
38. TGF-β Pathway: From Suppressor to Metastasis Promoter
39. Tumor Angiogenesis: the Angiogenic Switch
40. · The angiogenic switch
41. Invasion, Metastasis and Epithelial-Mesenchymal Transition (EMT)
42. · The metastatic cascade
43. · Epithelial-Mesenchymal Transition (EMT)
44. Tumor Microenvironment (TME)
45. · Composition and function of the TME
46. Tumor Immunoediting and Immune Escape
47. · The three E's: Elimination, Balance and Escape
48. Telomeres, Telomerase and Replicative Immortality
49. · Telomere biology
50. · Reactivation of telomerase in cancer
51. Molecular Targeted Therapy in Oncology
52. · Principles of targeted therapy
53. Cellular Immunotherapy: CAR-T, TILs and TCR-T
54. · CAR-T cells
55. Mechanisms of Resistance to Antineoplastic Therapy
56. · Intrinsic and acquired resistance
57. Precision Medicine in Oncology: Present and Future
58. · From histological diagnosis to molecular diagnosis
59. · Basket, umbrella and adaptive trials
60. · Future perspectives