Infectology: Special Situations | Advanced Medical Reference Manual

Internal Medicine · Clinical Specialties

How it begins

An advanced reference guide for the clinical, diagnostic, and pharmacotherapeutic management of infections in immunocompromised patients, transplant recipients, patients with advanced HIV, and special clinical situations (pregnancy, cirrhosis, renal dysfunction, asplenia, and difficult-to-control sepsis).

What it covers

1. Pathophysiology of Immunocompromize and Infectious Susceptibility
2. · Physiopathological Classification of Immunodeficiencies
3. Risk Stratification, Definitions and Microbiology
4. · Operational Definition
5. Therapeutic Strategy, Escalation and Management of Fungal Infections
6. · First Line Empirical Antibiotic Treatment
7. · Persistence of Fever: Approach on Day +4 to +7
8. Chronology of Post-Transplant Infection
9. · Infection Risk Timeline
10. High Impact Opportunistic Infections: CMV, EBV and BK Nephropathy
11. · Cytomegalovirus (CMV): The Cardinal Opportunistic Pathogen
12. · Epstein-Barr Virus (EBV) and Post-Transplant Lymphoproliferative Disorder (PTLD)
13. Hematopoietic Stem Transplantation (HSCT)
14. · Physiopathological Differences: Allogeneic vs. Autologous
15. Infections Associated with Biological Therapies and Small Molecules
16. · Key Drugs and Their Specific Infectious Risk
17. Advanced immunosuppression, Viral Load Management and Clinical Infections
18. · The Patient with HIV and CD4 Count 200 cells/µL
19. Opportunistic Infections of the Central Nervous System
20. · Meningeal cryptococcosis (Cryptococcus neoformans)
21. · Cerebral Toxoplasmosis (Toxoplasma gondii)
22. Opportunistic Pulmonary Infections and Disseminated Infections
23. · Pneumocystis jirovecii pneumonia (PCP)
24. · Tuberculosis (TB) and Mycobacterium avium Complex (MAC)
25. Inflammatory Immune Reconstitution Syndrome (IRIS)
26. · Clinical Classification
27. Immunosenescence and Infections in the Elderly
28. · The Physiology of Immunosenescence
29. Infections in Pregnant Patients and Antimicrobials
30. · Antimicrobial Safety in Pregnancy
31. Infections in Cirrhotic Patients and Liver Failure
32. · Spontaneous Bacterial Peritonitis (SBP)
33. Dose Adjustments in Renal Failure and Peritonitis due to Peritoneal Dialysis
34. · Calculation of Kidney Function and Principles of PK/PD
35. · Peritonitis in Peritoneal Dialysis (PD)
36. Infections in the Asplenic Patient and Prevention of Fulminant Sepsis
37. · The Immunological Role of the Spleen
38. · Immunization Protocol for Splenectomized Patients
39. Health Care Associated Infections (HCI) and Management of Multidrug Resistance
40. · Critical Resistance Mechanisms in Gram Negatives
41. Cardiovascular Device Infections and Infectious Endocarditis
42. · Infections Associated with Cardiovascular Devices (Pacemaker, ICD)
43. · Complex Infectious Endocarditis
44. Infections of Central Nervous System Branches and Nosocomial Meningitis
45. · Ventriculoperitoneal shunt infections (VPD) and external drainage (EVD)
46. Sepsis, Septic Shock and Pathophysiology of Organ Dysfunction
47. · Screening and Evaluation Tools: qSOFA and SOFA Scale
48. · The First Hour Measures Package (Surviving Sepsis Campaign 2021)