Adaptive Immunity — Medical Immunology

Immunology · Basic Sciences

How it begins

Adaptive immunity (also called acquired or specific immunity) constitutes the second major pillar of the immune system of jawed vertebrates. Unlike innate immunity, which operates through stereotyped recognition patterns and immediate response, the adaptive system is capable of generating antigen binding receptors of practically unlimited specificity, mounting...

What it covers

1. Adaptive Immunity
2. Introduction and Fundamental Properties
3. · Defining Properties of the Adaptive System
4. · Innate Immunity vs. Adaptive Immunity
5. · Main Cellular Components
6. T Lymphocyte Biology
7. · Ontogeny and Thymic Development
8. · T Cell Receptor (TCR) and CD3 Complex
9. · T Lymphocyte Activation: The Three Signals
10. · CD4+ Helper T Lymphocyte Subpopulations
11. · Cytotoxic CD8+ T Lymphocytes (CTL)
12. · Regulatory T lymphocytes (Treg)
13. Major Histocompatibility and Antigenic Presentation Complex
14. · Antigenic Processing and Presentation Routes
15. · Professional Antigen Presenting Cells
16. B Lymphocyte Biology and Humoral Response
17. · Development of the B Lymphocyte in the Bone Marrow
18. · B Lymphocyte Activation and Germinal Center Reactions
19. Antibodies: Structure, Isotypes and Effector Functions
20. · Human Immunoglobulin Isotypes
21. · Effective Mechanisms of Antibodies
22. Immunological Memory
23. · Primary vs. secondary response
24. Immunological Tolerance
25. · Central Tolerance
26. · Peripheral Tolerance
27. Advanced Clinical Correlations
28. · Primary Immunodeficiencies Related to the Adaptive System
29. · Autoimmunity: Molecular Mechanisms
30. · Hypersensitivity: Gell and Coombs Classification
31. · Transplant Rejection
32. · Cancer Immunotherapy
33. · Immunological Principles of Vaccination
34. Integration of Effector Mechanisms: Adaptive and Innate
35. · The Complement as an Effector of the Humoral Response
36. · Adaptive-Innate Interaction: Amplification Circuits
37. · Immunosenescence: The Aging of the Adaptive System