Pain Medicine: Acute and Postoperative Pain — Anesthetic and Algological Specialty Treaty

Pain Medicine · Clinical Specialties

How it begins

A comprehensive and detailed treatise on the neurobiology of nociception, central modulation, the development of spinal sensitization and the design of precision multimodal analgesia strategies aimed at avoiding the transition to chronicity.

What it covers

1. Introduction and Ethics of Pain Relief: The Human and Physiological Dimension of Postoperative Pain
2. Peripheral Receptors and Signal Transduction: Primary Alarm Mechanisms
3. · Cellular mechanics of dermoepidermal transduction
4. A-delta and C fibers: Speed, Structure and Distribution of Afferent Pathways
5. · Biophysical differences in peripheral transmission
6. Synaptic Transmission in the Dorsal Horn: The First Relay and Spinal Modulation
7. · Microanatomy of the posterior horn and chemical neurotransmission
8. Ascending Pathways and Pain Matrix: The Journey of Sensory Information to the Brain
9. · Medullary tracts and supraspinal integration
10. Downward Modulation: The Endogenous Brake of the Nociceptive Signal
11. · Inhibitory and facilitatory pathways of central control
12. Peripheral Sensitization: Physiology of Inflammatory Soup
13. · The microenvironment of the surgical wound
14. Central Sensitization and Hyperalgesia: The Spinal Amplification Process
15. · The Wind-Up phenomenon and synaptic plasticity
16. Glia and Spinal Neuroinflammation: The Silent Role of Central Immunity
17. · Microglial and astrocyte activation
18. Transition from Acute to Chronic Pain: Physiology of Postoperative Chronification
19. · From physiological nociception to neuropathy induced by surgery
20. Systemic Pathophysiology and Clinical Responses to Acute Uncontrolled Pain
21. · The multi-organ impact of nociceptive aggression
22. Pain Metrology and Clinical Scales: The Search for Objective Measurement
23. · Multidimensional evaluation of the painful phenomenon
24. Psychosocial and Predictive Factors: The Cognitive Filter of Surgical Stimulus
25. · The impact of the psyche on spinal processing
26. Pharmacogenomics and Special Populations: The Personalization of Analgesic Management
27. · Genetic polymorphisms of Cytochrome P450
28. · Management of vulnerable populations
29. Intraoperative Nociception Monitoring: Objectifying the Response to Pain Under General Anesthesia
30. · Beyond conventional hemodynamic control
31. NSAIDs, Coxibs and Anti-inflammatories: Modulating the Origin of the Inflammatory Soup
32. · Mechanism of biochemical action and isoform selectivity
33. Paracetamol and Metamizole: Centrally Acting Non-Opioid Analgesics
34. · Paracetamol (Acetaminophen): Precision central mechanism of action
35. · Metamizole (Dipyrone): The highly effective spasmolytic analgesic
36. Systemic Opioids: Receptive Pharmacodynamics and Precision Clinical Profiles
37. · Molecular interaction and second messenger cascade
38. · Pharmacological Profiles of Commonly Used Opioids
39. Acute Opioid Tolerance and Hyperalgesia: The Paradoxes of Prolonged Opioid Therapy
40. · Two clinical entities with dissimilar molecular bases
41. Adjuvants in Acute Pain: Non-Opioid Synaptic Modulators
42. · Synaptic and neurochemical stabilization mechanisms
43. Local Anesthetics and Conduction Block: The Disruption of the Transmission Line
44. · Chemical structure and interaction with the Sodium channel
45. Neuroaxial Analgesia: Epidural and Intrathecal Control of Visceral Stimulus
46. · Modulation at the level of the spinal cord
47. Chest and Abdominal Wall Blocks: Ultrasound Applied to Wall Analgesia
48. · Ultrasound anatomy and fascial safety planes
49. Limb Blocks and Neuromonitoring: Selective Surgical Analgesia
50. · Plexus and peripheral nerve blocks under dual guidance
51. Patient Controlled Analgesia (PCA): Programming and Critical Safety Parameters
52. · The empowerment of the patient in the control of their analgesia
53. Preventive Analgesia and ERAS Protocols: Systemic Multimodal Planning
54. · The concept of preemptive analgesia (*Preemptive Analgesia*)
55. Pain in Major Abdominal and Thoracic Surgery: The Challenge of Acute Management
56. · Specific multimodal approaches of high complexity
57. Patients with Previous Tolerance and Addictions: The Scenario of High Algological Complexity
58. · Management of patients with chronic pain on chronic treatment with Opioids
59. Systemic Toxicity from Local Anesthetics: Emergency Diagnosis and Lipid Rescue
60. · Pathophysiology of systemic cellular collapse
61. Acute Pain Units (AUD): Organizational Structure and Quality Control of Care
62. · The clinical impact of specialized equipment