Legal Medicine: Forensic Toxicology

Legal Medicine · Clinical Bases

How it begins

Exhaustive study of toxins with medical-legal significance: concepts and classification, toxicokinetics and toxicodynamics, the diagnosis of poisoning in the living and in the corpse, the taking and conservation of samples, toxicological analysis (screening and confirmation), postmortem redistribution, and the monographic study of the large groups of poisons—caustics, gases, pesticides, metals, alcohol,...

What it covers

1. Concept of Forensic Toxicology and Poison
2. · The three branches of toxicology
3. · The questions of forensic toxicology
4. Classification of Toxics
5. · According to the chemical nature
6. · According to the target organ (toxicodynamic criterion)
7. · According to the medical-legal etiology
8. Toxicokinetics: the Journey of the Toxic
9. · Absorption routes
10. · Distribution
11. · Metabolism (biotransformation)
12. · Elimination and quantitative concepts
13. Toxicodynamics: Mechanisms of Action
14. · Fundamental mechanisms of toxicity
15. · Dose-response relationship and thresholds
16. · Factors that modify toxicity
17. Medico-Legal Diagnosis of Intoxication
18. · Toxicological syndromes ("toxidromes")
19. Taking, Conservation and Custody of Samples
20. · Biological matrices and their value
21. · Conservation
22. Toxicological Analysis
23. · Screening methods
24. · Confirmation and quantification methods
25. · Validation and quality assurance
26. Postmortem Toxicology: Redistribution and Interpretation
27. · Postmortem redistribution (PMR)
28. · Neoformation and postmortem degradation
29. · Keys for prudent interpretation
30. Caustics: Acids and Alkalis
31. · Findings and course
32. Toxic Gases: Carbon Monoxide and Cyanide
33. · Carbon monoxide (CO)
34. · Cyanide (CN⁻)
35. Pesticides
36. · Organophosphates and carbamates
37. · Paraquat (bipyridyl herbicide)
38. · Anticoagulant rodenticides
39. Metals and Metalloids
40. Ethyl Alcohol and Toxic Alcohols
41. · Toxicokinetics of ethanol
42. · Clinical-legal correlation of alcohol level
43. · Toxic non-ethyl alcohols
44. Drugs of Abuse
45. Drug Poisoning
46. · Insulin and "death without a trace"
47. Chemical Submission
48. · Characteristics of the "ideal" agent for submission
49. Integrative Synthesis