Clinical Nutrition — TCA and Drug Interactions

Clinical Nutrition · Clinical Specialties

How it begins

An advanced clinical analysis on the pathophysiology, diagnosis and interventions in Eating Disorders (ED), the metabolic dynamics of Refeeding Syndrome and the critical pharmacokinetic and pharmacodynamic interactions between nutrients and therapeutic agents.

What it covers

1. Neurobiology of Food Regulation
2. · The Homeostatic Pathway: The Arcuate Nucleus (ARC)
3. · Peripheral Signals and the Entero-Cerebral Axis
4. · The Hedonic Pathway and its Dysfunction in EDs
5. Classification and Diagnostic Criteria of EDs
6. · 1. Anorexia Nervosa (AN)
7. · 2. Bulimia Nervosa (BN)
8. · 3. Binge Eating Disorder
9. · 4. Avoidant/Restrictive Food Intake Disorder (ARFID/TARA)
10. Systemic Pathophysiology and Organic Complications
11. · 1. Cardiovascular Complications
12. · 2. Endocrine and Hypothalamic-Pituitary Complications
13. · 3. Gastrointestinal disorders
14. · 4. Electrolyte Alterations and Kidney Function
15. · 5. Hematological and Immunological Complications
16. Advanced Nutritional Evaluation
17. · Establishing Target Weight and Body Composition
18. · Useful Analytical Biomarkers in Monitoring
19. · Assessment of the Basal Metabolic Rate
20. Refeeding Syndrome (RS)
21. · Pathophysiology: The Transition from Catabolism to Anabolism
22. · Clinical Manifestations of Electrolyte Deficiency
23. · Risk Stratification (NICE Criteria)
24. · Clinical Protocol for the Prevention and Management of SR
25. Integrated Nutritional-Pharmacological Treatment
26. · Nutritional Rehabilitation: Macronutrient Progression
27. · Evidence-Based Pharmacotherapy
28. Fundamentals of Drug-Nutrient Interactions
29. Interactions in the Gastrointestinal Tract
30. · Absorption Modulation: Physiological Mechanisms
31. · Chelation Phenomenon and Direct Chemical Incompatibility
32. Modulation of Drug Metabolism by Food
33. · 1. Enzyme Inhibition: The Effect of Grapefruit Juice
34. · 2. Enzyme Induction: Grilled and Cruciferous Foods
35. · 3. Modulation of Transporters: P-Glycoprotein (P-gp)
36. Drugs That Alter Nutritional Status
37. · 1. Drugs That Induce Nutrient Malabsorption
38. · 2. Drug-Induced Modulation of Body Weight
39. Interactions in Pharmacopsychiatry Applied to EDs
40. · 1. Monoamine Oxidase Inhibitors (MAOI) and Tyramine: "The Cheese Effect"
41. · 2. Lithium Carbonate, Sodium and Hydration
42. Interactions in Enteral and Parenteral Nutritional Support
43. · 1. Enteral Nutrition and Medications: Physical-Chemical Incompatibilities
44. · 2. Parenteral Nutrition: The Danger of Precipitated Calcium and Phosphorus
45. · 3. Destabilization of Lipid Emulsions in Parenteral
46. Monitoring Protocol and Alarm Signals
47. · Intervention Algorithm and Analytical Monitoring Frequency
48. · Expert Level Critical Alarm Thresholds
49. Clinical Cases and Advanced Medical Correlations
50. · Clinical Case 1: Management of Extreme Anorexia Nervosa, Refeeding Syndrome and QTc Prolongation
51. · Clinical Case 2: Critical Drug-Nutrient Interaction due to MAOI and Enteral Nutrition Obstruction