General Principles of Organ Transplantation — General Surgery and Specialties

Surgery · Clinical Specialties

How it begins

Comprehensive compendium of cell biology, preservation techniques, immunological alloreactivity, advanced immunosuppressive pharmacology and surgical approaches to organ replacement therapy.

What it covers

1. Historical Evolution, Epidemiology and Ethical Frameworks
2. · Epidemiology and the Transplant Gap
3. · International Ethical and Legal Frameworks
4. Transplant Immunology (Allophysiology)
5. · Structure and Expression of HLA Molecules
6. · Allogeneic Recognition Pathways
7. · The T Lymphite Activation Cascade: Three Signals
8. Clinical-Pathological Mechanisms of Rejection
9. · Hyperacute Rejection
10. · Acute Cellular Rejection (TCMR)
11. · Acute Humoral/Antibody-Mediated Rejection (AMR)
12. · Chronic Rejection and Allograft Vasculopathy
13. Compatibility Evaluation and Immunogenetic Typing
14. · HLA Molecular Typing
15. · Calculation of the antibody reactivity panel (cPRA)
16. · Antibody Screening Strategies
17. Brain Death and Pathophysiology of the Cadaveric Donor
18. · Pathophysiology of the Donor in Brain Death
19. · Endocrine-Metabolic Disorders and Hormone Replacement Therapy (HRT)
20. Organ Preservation and Pathophysiology of Ischemia-Reperfusion
21. · Pathophysiology of Cellular Ischemia
22. · The Reperfusion Paradox: Oxygen-Mediated Damage
23. · Physiological Preservation Solutions
24. · Technological Evolution: Machine Perfusion
25. Surgical Principles of Procurement and Implantation
26. · Multiorgan Harvest Surgery (Procura)
27. · Bench Surgery
28. Advanced Pharmacology of Immunosuppression
29. · Immune Induction Therapy
30. · Maintenance Therapy: The Triple Standard Scheme
31. Chronology of Opportunistic Infections and Systemic Complications
32. · Post-Transplant Lymphoproliferative Disorders (PTLD)
33. Surgical and Clinical Particularities by Solid Organ
34. · 1. Kidney Transplant
35. · 2. Liver Transplant
36. · 3. Heart Transplant
37. · 4. Lung Transplant
38. Xenotransplantation, Immunological Tolerance and the Future of Transplant Surgery
39. · Precision Xenotransplantation: Gene Editing of Porcine Platforms
40. · Induction of Immunological Tolerance and Mixed Chimerism