High Complexity Neonatology Treatise: The Premature Neonate and Restricted Intrauterine Growth (FGR)

Neonatology · Clinical Specialties

How it begins

An advanced and exhaustive scientific compendium that details the biological transition, hemodynamic imbalances, pulmonary molecular biology, neurodevelopmental complications and the critical therapeutics of very low weight preterm newborns and those affected by severe placental insufficiency.

What it covers

1. Definition, Phenotypic Differentiation and Diagnostic Criteria (PEG vs. FGR)
2. Placental Pathophysiology and Uterine Vascular Remodeling
3. Advanced Doppler Hemodynamics and Fetal Flow Redistribution
4. · 1. Umbilical artery (UA)
5. · 2. Middle Cerebral Artery (MCA) and "Brain-Sparing"
6. · 3. Cerebroplacental Ratio (CPR)
7. · 4. Venous Duct (Ductus Venosus - DV)
8. Management Strategies, Completion Criteria and Clinical Trials
9. · Fundamental Clinical Trials
10. · Management Stratification (Barcelona Clinical Protocol)
11. Adaptation and Neonatal Morbidities of the Newborn with FGR
12. · 1. Metabolic Instability: Hypoglycemia and Hypothermia
13. · 2. Polycythemia and Hyperviscosity Syndrome
14. · 3. Neutropenia and Functional Immunodeficiency
15. Thermoregulation, Transepidermal Losses and Skin Barrier
16. · Structural Immaturity of the Skin Barrier
17. · Biophysical Mechanisms of Heat Loss
18. · Physiology of Brown Fat and Impossibility of Chemical Thermogenesis
19. Pulmonary Physiology, Alveologenesis and Surfactant Immaturity
20. · Phases of Lung Development
21. · Composition and Molecular Biology of Pulmonary Surfactant
22. · Alveolar Biophysics: Laplace's Law
23. Cardiovascular Transition and Preterm Neonatal Hemodynamics
24. · Physiological Events of the Transition
25. · Particularities of Premature Myocardium
26. Gastrointestinal Physiology, Nutritional Requirements and Immaturity of the Enteric Barrier
27. · Gastrointestinal Structural and Functional Immaturity
28. · Acute Onset Total Parenteral Nutrition (TPN)
29. · Early Trophic Enteral Nutrition (ETN)
30. Neurological Physiology, Cerebral Autoregulation and Vascular Vulnerability
31. · 1. The Germinal Matrix (MG)
32. · 2. Absence of Cerebral Autoregulation (Pressure-Passive Circulation)
33. Renal Immaturity and Acute Hydroelectrolyte Homeostasis
34. · Physiological Characteristics of Kidney Function
35. · The Three Phases of Postnatal Hydroelectrolyte Adaptation
36. Immunology and Hematology of Extreme Prematurity
37. · Immunology: A Systemic Vulnerability
38. · Hematology: Anemia of Prematurity
39. Bronchopulmonary Dysplasia (BPD): "Classic" vs. "New" DBP and its Current Management
40. · Differentiated Pathophysiology: "Classic" vs. "New" DBP
41. · Factors of Pulmonary Injury (Physiopathological Mechanisms)
42. Hemodynamically Significant Patent Ductus Arteriosus (PCA)
43. · Pathophysiology of the Left-to-right Shunt
44. · Hemodynamic Significance Criteria using Functional Echocardiography
45. · Medical and Surgical Therapeutics
46. Necrotizing Enterocolitis (NEC): Pathobiology and Multidisciplinary Intervention
47. · Pathophysiology: The TLR-4 Receptor Common Pathway
48. · Modified Bell Classification Criteria
49. Retinopathy of Prematurity (ROP): Retinal Angiogenesis and Treatment
50. · Biphasic Pathophysiology of the Disease
51. Intraventricular Hemorrhage (IVH) and Post-hemorrhagic Ventricular Dilation
52. · Papille Classification (Grading by Brain Ultrasound)
53. · Prevention Strategies: The "Neuroprotective Care Bundles"
54. · Post-hemorrhagic Ventricular Dilation (PHDV)
55. Apnea of Prematurity and Pharmacology of Caffeine Citrate
56. · Pathophysiology: Immaturity of Respiratory Control
57. · Pharmacology of Caffeine Citrate
58. Early (EOS) and Late Neonatal Sepsis (the): Criteria, Diagnosis and Therapeutics
59. · 1. Vertical or Early Transmission Sepsis (Early-Onset Sepsis - EOS)
60. · 2. Nosocomial or Late Sepsis (Late-Onset Sepsis - the)
61. · Kinetics and Utility of Infectious Biomarkers
62. · Empirical Antibiotherapy Schemes of Choice
63. Neurodevelopment of Extreme Prematurity and Long-Term Metabolic Impact in FGR
64. · 1. Neurodevelopment and Neurological Sequelae
65. · 2. Metabolic "Mismatch" in Newborns with FGR: The Barker Hypothesis
66. Decisional Algorithm in the Management of Respiratory Difficulty and hsPCA