Clinical Biochemistry of Neurological Diseases | Treaty of Neurochemistry and Molecular Diagnostics

Biochemistry · Basic Sciences

How it begins

An exhaustive analysis of the molecular mechanisms that govern pathologies of the central and peripheral nervous system. From the kinetics of protein translocation and amyloidogenic proteopathies, to the quantitative study of cerebrospinal fluid using electrofocusing, mass spectrometry of plasma biomarkers and the molecular genetics of channelopathies.

What it covers

1. Neurological Clinical Biochemistry
2. Blood Brain Barrier (BBB) and Biochemical Analysis of CSF
3. · 1.1 · Protein Structure of Tight Junctions and Transport System
4. · 1.2 · Biochemistry of CSF Production and Composition
5. · 1.3 · Diagnostic Biochemical Parameters in CSF
6. Neurodegenerative Diseases I: Amyloid Proteopathies (Alzheimer's)
7. · 2.1 · Amyloid Precursor Protein (APP) Processing
8. · 2.2 · Amyloid Cascade Hypothesis and Tau Pathology
9. · 2.3 · Biochemical Biomarkers of Alzheimer's in Clinical Presentation
10. Neurodegenerative Diseases II: Synucleinopathies and Lysosomal Dysfunction
11. · 3.1 · Conformational Dynamics and Aggregation of α-synuclein
12. · 3.2 · Aggregate Seeding Tests in Diagnostics: RT-QuIC
13. Motoneuron Diseases and Systemic Atrophies: ALS and Huntington's
14. · 4.1 · Amyotrophic Lateral Sclerosis: Mechanisms of TDP-43 and C9orf72 Toxicity
15. · 4.2 · Huntington's Disease: Biochemistry of the Polyglutamine Domain
16. Multiple Sclerosis and Neuroimmune Demyelinating Diseases
17. · 5.1 · Immunochemical Physiopathology of Demyelinating Plaque
18. · 5.2 · Isoelectrofocusing of CSF and Detection of Oligoclonal Bands (BOC)
19. · 5.3 · Differential Diagnosis of NMOSD and MOGAD
20. Molecular Pathophysiology of Cerebral Ischemia and Acute Biomarkers
21. · 6.1 · Pathophysiology of Ischemic Cellular Injury
22. · 6.2 · Biochemical Markers of Acute Brain Injury
23. Chanalopathies, Epileptogenesis and Neurotransmission
24. · 7.1 · Physiology of Excitatory Neurotransmission vs. inhibitory
25. · 7.2 · Molecular Physiopathology of SCN1A Sodium Channel Channelopathies
26. · 7.3 · Dynamics of Intracellular Chlorine in Acquired Epileptogenesis
27. Metabolic, Toxic and Nutritional Encephalopathies
28. · 8.1 · Hepatic Encephalopathy: Ammonia Metabolism and Astrocytic Edema
29. · 8.2 · Nutritional Encephalopathies: Wernicke-Korsakoff and Combined Degeneration
30. Mitochondrial Dysfunction and Energy Metabolism Diseases
31. · 9.1 · Physiology of the Electron Transport Chain (OXPHOS)
32. · 9.2 · Diagnostic Biochemistry: Lactic Acidosis and the Lactate/Pyruvate Ratio
33. Pathophysiology and Biochemistry of Prion Diseases
34. · 10.1 · Structural Transition from PrPC to PrPSc
35. · 10.2 · Prion Disease Biomarker Panel in CSF
36. Biochemical Markers and Molecular Genetics in Neuro-oncology
37. · 11.1 · IDH1/IDH2 Mutation and the 2-Hydroxyglutarate Oncometabolite Pathway
38. · 11.2 · 1p/19q Codeletion and MGMT Promoter Methylation Status
39. · 11.3 · Paraneoplastic Neurological Syndromes and Autoantibodies
40. Lysosomal and Fatty Acid Storage Diseases (VLCFA)
41. · 12.1 · Sphingolipidosis: Enzymatic Physiopathology of Gaucher, Tay-Sachs and Niemann-Pick
42. · 12.2 · X-Linked Adrenoleukodystrophy (X-ALD): Biochemistry of VLCFAs
43. · 12.3 · Profile of Very Long Chain Fatty Acids in Laboratory Diagnostics