Clinical Biochemistry of Neurotransmitters

Clinical Biochemistry of Neurotransmitters — Expert Level

How it begins

Chemical neurotransmission is the fundamental process by which neurons communicate with their effector cells. The initiation of this event lies in the conversion of an electrical signal (the action potential) into a diffusible chemical signal. This biological transducer depends on the regulated opening of N- and P/Q-type voltage-gated calcium channels (VGCC), located at critical densities of…

What it covers

1. Excitation-Secretion Coupling and Vesicular Machinery
2. Excitatory Amino Acids: The Glutamatergic System
3. · Glutamate Receptors
4. Inhibitory Amino Acids: The GABAergic and Glycinergic Systems
5. · γ-aminobutyric acid (GABA)
6. · Glycine
7. Cholinergic Transmission
8. · Biosynthesis and Storage
9. · Cholinergic Receptors
10. · Neurotransmitter Elimination: Enzymatic Degradation
11. The Dopaminergic System
12. · Biosynthesis and Storage
13. · Dopamine Receptors
14. · Main Dopaminergic Pathways of the Brain
15. The Noradrenergic and Adrenergic System
16. · Vesicular Biosynthesis and Storage
17. · Adrenergic Receptors
18. The Serotoninergic and Histaminergic Systems
19. · Serotonin
20. · Histamine
21. Purinergic Transmission
22. · ATP as a Vesicular Neurotransmitter
23. · Purinergic Signaling: The Concept of Ectonucleotidases
24. · Purinergic Receptors
25. Endogenous Neuropeptides and Opioids
26. · Biosynthesis, Processing and Axonal Transport
27. · The Endogenous Opioid System
28. Transmitter Gases and Retrograde Messengers
29. · Transmitting Gases (Gasotransmitters)
30. · Retrograde Signaling by Endocannabinoids
31. Compendium of Clinical Correlations and Drug Targets