Clinical Biochemistry: Metabolism of Xenobiotics - Reference Treatise and Physiopathological Correlation

Biochemistry · Basic Sciences

How it begins

Enzymatic mechanisms of functionalization and conjugation, transmembrane transport systems, molecular and transcriptional regulation through nuclear receptors, population pharmacogenetics, clinical toxicology of bioactivation and complex metabolic interactions in the human organism.

What it covers

1. · Structural Classification of Xenobiotics
2. · The Cytochrome P450 (CYP) Superfamily
3. · The Stages of the Catalytic Cycle
4. · Conjugation Pathways and Endogenous Cofactors
5. · The ABC Family Efflux Machinery
6. · The Family of Ligand-Sensitive Nuclear Receptors
7. · Phenotypic Classification of Metabolizers
8. · Bioactivation and Electrophilic Stress
9. · Neonatal and Pediatric Metabolism
10. · Complex Diagnostic Clinical Vignettes
11. · Integrating Clinical and Neurosurgical Decision Matrix