Clinical Biochemistry — Glucocorticoids

Biochemistry · Basic Sciences

How it begins

Comprehensive, expert-level treatise on the biochemistry of glucocorticoids. From deep mitochondrial steroidogenesis and the molecular dynamics of the NR3C1 receptor to advanced analytical protocols and differential clinical interpretation of adrenal pathology.

What it covers

1. Chemical Structure and Biosynthesis in the Adrenal Cortex
2. Regulation of the Hypothalamus-Pituitary-Adrenal Axis (HPA)
3. · Neuroendocrine cascade mechanism
4. The Glucocorticoid Receptor (GR/NR3C1)
5. · Molecular biology of the receptor
6. Genomic Mechanisms: Transactivation and Transrepression
7. Fast Non-Genomic Pathways
8. Physiological and Metabolic Actions: Hydrocarbon Metabolism
9. Protein and Lipid Metabolism
10. · Deep protein catabolism
11. · Lipid metabolism with bimodal distribution
12. Hydroelectrolyte Balance and Cardiovascular Effects
13. · Vascular sensitization and pressor tone
14. · Effects on renal sodium and water transport
15. Effects on Bone and Connective Tissue
16. · Glucocorticoid-induced osteoporosis (GIOP)
17. Immune and Inflammatory Regulation: Deep Immunosuppression
18. Laboratory Analytical Phase: Cortisol Transport
19. · Molecular distribution in serum
20. Analytical Methods for Cortisol Determination
21. Functional Dynamic Tests of the HPA Axis
22. Pathology of Excess: Cushing's Syndrome
23. · Physiopathological classification
24. Analytical Pathophysiology and Biochemical Alterations in Cushing
25. Hypercortisolism Diagnostic Algorithm
26. Default Pathology: Primary Adrenal Insufficiency
27. · Addison's disease: Destruction of the adrenal cortex
28. Secondary and Tertiary Adrenal Insufficiency
29. · Central defects of the HPA axis
30. Acute Adrenal Crisis and Emergency Protocol in the Laboratory
31. Congenital Adrenal Hyperplasia (CAH)
32. · Biosynthesis defect with compensatory stimulation
33. Diagnostic Steroid Profiles in HSC
34. Clinical Pharmacology of Synthetic Glucocorticoids
35. · Chemical structural modifications
36. Mechanisms of Resistance to Glucocorticoids
37. Clinical Cases and Interpretation of Biochemical Profiles