Palliative Care: Control of Non-Painful Symptoms | Treatise on Palliative Medicine and Continuous Support

Palliative Care · Clinical Specialties

How it begins

A comprehensive analysis of the palliative management of non-painful symptoms in patients with advanced oncological and non-oncological disease. From the neurochemistry of dyspnea and emesis to the molecular control of delirium, malignant intestinal obstruction, neurovegetative disorders and palliative sedation based on clinical evidence.

What it covers

1. Control of Non-Painful Symptoms
2. Dyspnea in the Patient in the Advanced and Terminal Phase
3. · 1.1 · Pathophysiology of Dyspnea: Receptor Circuits and Central Pathways
4. · 1.2 · Pharmacotherapy of Dyspnea: Opioids and Adjuvants
5. · 1.3 · Non-Pharmacological Measures and Physical Approach
6. Premortem Rales and Management of Respiratory Secretions
7. · 2.1 · Pathophysiological Types of Rales
8. · 2.2 · Comparative Anticholinergic Pharmacotherapy
9. · 2.3 · Non-Pharmacological Interventions and Positioning
10. Cough and Hemoptysis in the Palliative Patient
11. · 3.1 · Pathophysiology of the Cough Reflex and Antitussive Therapy
12. · 3.2 · Approach to Mild to Moderate Hemoptysis
13. · 3.3 · Action Protocol for Catastrophic Hemoptysis
14. Emesis Pathophysiology and Key Receptors
15. · 4.1 · The Vomiting Center and the Four Ways of Activation
16. · 4.2 · The Role of the NK1 Receptor in Late Emesis
17. Directed Pharmacological Treatment of Nausea and Vomiting
18. · 5.1 · Antiemetic Drugs and Receptor Affinity Profiles
19. · 5.2 · Antiemetic Rotation and Selection Algorithm
20. Malignant Intestinal Obstruction (MIO) in Cancer Patients
21. · 6.1 · Pathophysiology of the Secret-Exudative Cycle in MIO
22. · 6.2 · Pharmacotherapy of Non-Surgical IOM
23. · 6.3 · Clinical Debate: Nasogastric Decompression Tube vs. Palliative Gastrostomy
24. Constipation/Constipation Associated with Opioids
25. · 7.1 · Pathophysiology of Enteric Opioid Receptors
26. · 7.2 · Pharmacological Management: Classic Laxatives and PAMORAs
27. · 7.3 · Prevention and Support Interventions
28. Anorexia-Neoplastic Cachexia Syndrome (ACS)
29. · 8.1 · Immunology of Cachectizing Metabolic Deviation
30. · 8.2 · Pharmacotherapy of Appetite and Weight Modulation
31. · 8.3 · Ethical Considerations of Artificial Nutrition and Hydration
32. Xerostomia, Sialorrhea and Refractory Hiccups in Advanced Disease
33. · 9.1 · Physiology of Oral Dryness and Sialorrhea
34. · 9.2 · Pathophysiology and Management of Refractory Hiccups
35. Delirium and Terminal Agitation in the Palliative Critically Ill Patient
36. · 10.1 · Neurochemical Pathophysiology of Delirium
37. · 10.2 · Diagnosis and Clinical Screening
38. · 10.3 · Pharmacological Management of Delirium and Terminal Agitation
39. Anxiety, Depression and Insomnia in Palliative Care
40. · 11.1 · Pathophysiology of Anxiety and Insomnia in Palliative Patients
41. · 11.2 · Pharmacotherapeutic Approach to Anxiety and Depression
42. · 11.3 · Insomnia Management Strategies
43. Myoclonus and Opioid-Induced Neurotoxicity (OIN)
44. · 12.1 · Pathophysiology of OIP and Role of the M3G Metabolite
45. · 12.2 · Opioid Rotation as a Rescue Strategy
46. · 12.3 · Seizure Control in the Final Phase
47. Asthenia, Fatigue and Palliative Functional Cachexia
48. · 13.1 · Immunometabolic Pathobiology of Fatigue
49. · 13.2 · Pharmacological Approach and Use of Psychostimulants
50. · 13.3 · Functional Adaptation and Non-Pharmacological Support
51. Pruritus and Profuse Diaphoresis in Palliative Care
52. · 14.1 · Pathophysiology of the Pruritus and Diaphoresis Pathways
53. · 14.2 · Directed Pharmacological Treatment
54. · 14.3 · Physical Measurements and Skin Care
55. Malignant Neoplastic Wounds, Ulcers and Odor Control
56. · 15.1 · Pathobiology of Anaerobic Infections and Odor Control
57. · 15.2 · Control of Exudate and Prevention of Local Bleeding
58. Palliative Sedation and Symptom Control in the Agonizing Phase
59. · 16.1 · Ethical-Legal Differentiation between Palliative Sedation and Euthanasia
60. · 16.2 · Palliative Sedation Induction Algorithm
61. · 16.3 · Management of Second Line Sedatives and Rescue in Agony
62. · 16.4 · Fundamental Principles in the Control of Non-Painful Symptoms