Clinical Epidemiology and Evidence-Based Medicine | Scientific Methodology Treatise

Public Health and Epidemiology · Clinical Bases

How it begins

Comprehensive treatise on the logical and quantitative foundations that govern contemporary clinical practice. It addresses the construction of causal inference under formal criteria, analytical epidemiological designs, the mathematical treatment of biases and confounding variables, the analytical development of diagnostic tests and survival models, quantitative synthesis through meta-analysis, the framework...

What it covers

1. Clinical Epidemiology and EBM
2. Fundamentals of Clinical Epidemiology and Causal Inference
3. · 1.1 · Epistemology of Causal Inference
4. · 1.2 · Frequency Measurements in Epidemiology
5. · 1.3 · Association and Impact Measures
6. Intervention Studies: Randomized Clinical Trials
7. · 2.1 · The Randomization Process and Bias Control
8. · 2.2 · Analysis Populations: Intention to Treat vs. By Protocol
9. · 2.3 · Complex and Innovative ECA Designs
10. Analytical Observational Studies: Cohorts and Case-Controls
11. · 3.1 · Architecture and Dynamics of Cohort Studies
12. · 3.2 · Architecture of Case and Control Studies
13. · 3.3 · Advanced Methodological Variants
14. Bias, Confusion and Effect Modification
15. · 4.1 · Taxonomy of Epidemiological Biases
16. · 4.2 · Confounding and its Methodological and Analytical Control
17. · 4.3 · Effect Modification (Interaction)
18. Diagnostic Tests: Validity, Safety and Analysis of ROC Curves
19. · 5.1 · Intrinsic Parameters of Diagnostic Validity
20. · 5.2 · Security Parameters: Predictive Values and Bayes' Theorem
21. · 5.3 · Likelihood Ratios
22. · 5.4 · Analysis of ROC Curves (Receiver Operating Characteristic)
23. Prognosis and Survival Studies
24. · 6.1 · Methodological Concept of Censorship
25. · 6.2 · Kaplan-Meier estimator
26. · 6.3 · Cox Proportional Hazards Regression Model
27. Evidence-Based Medicine: Asking Questions and Seeking Information
28. · 7.1 · Epistemological Paradigm and Historical Evolution
29. · 7.2 · Methodical Formulation of Clinical Questions: The PICO Acronym
30. · 7.3 · Systematic Bibliographic Search Strategies
31. Critical Reading of Scientific Literature: International Consortia
32. · 8.1 · Methodological Reporting Guidelines (Reporting Guidelines)
33. · 8.2 · Risk of Bias Assessment Tools
34. Systematic Reviews and Meta-Analyses
35. · 9.1 · Mathematical Data Combination Models
36. · 9.2 · Evaluation of Heterogeneity
37. · 9.3 · Publication Bias and Asymmetry Analysis
38. GRADE Gradation and Preparation of Clinical Practice Guides
39. · 10.1 · The Four Levels of Certainty of Evidence
40. · 10.2 · GRADE Certainty Evaluation Algorithm
41. · 10.3 · Determination of the Strength of the Recommendation
42. Inferential Biostatistics I: Hypothesis Contrast and Parametric Tests
43. · 11.1 · Probability of Error in Inference
44. · 11.2 · Methodical Selection of Statistical Tests
45. Inferential Biostatistics II: Multivariable Regression Models
46. · 12.1 · Multiple Linear Regression Model
47. · 12.2 · Multiple Logistic Regression Model
48. · 12.3 · Diagnostics and Advanced Model Assumptions
49. Pharmacoepidemiology and Phase IV Safety Studies
50. · 13.1 · Justification of post-marketing Pharmacovigilance Studies
51. · 13.2 · Pharmacovigilance Methods and Systems
52. · 13.3 · Active Pharmacovigilance and Inference with Real World Evidence
53. Genomic Epidemiology and Precision Medicine
54. · 14.1 · Genome Whole Association Studies (GWAS)
55. · 14.2 · Mendelian Randomization Methodology
56. Clinical Decision Making and Economic Impact
57. · 15.1 · Decision Tree Models and Markov Models
58. · 15.2 · Health Economic Evaluation Methods
59. · 15.3 · The Incremental Cost-Effectiveness Ratio (ICER)
60. Ethics in Clinical Research, Regulation and Scientific Integrity
61. · 16.1 · Historical Milestones in the Formulation of Medical Bioethics
62. · 16.2 · Main Deviations and Fraudulent Scientific Conduct
63. · 16.3 · Key Methodological Principles in Applied Clinical Epidemiology