Monoclonal Gammopathy

Monoclonal Gammopathy — Internal Medicine

How it begins

Monoclonal gammopathies comprise a spectrum of diseases characterized by the clonal proliferation of plasma cells or B lymphocytes that secrete a monoclonal immunoglobulin (M protein). From the asymptomatic premalignant state to disseminated multiple myeloma, this spectrum requires deep pathophysiological understanding, precise diagnostic criteria, and a stratified therapeutic approach.

What it covers

1. General Physiopathology
2. · Structure of Immunoglobulins and Protein M
3. MGUS — Monoclonal Gammopathy of Uncertain Significance
4. · MGUS Diagnostic Criteria
5. Quiescent Multiple Myeloma (Smoldering)
6. · SMM Diagnostic Criteria
7. Multiple Myeloma
8. · IMWG 2014 Diagnostic Criteria: CRAB + SLiM
9. · Clinical Manifestations of Multiple Myeloma
10. · Staging of Multiple Myeloma
11. · Complete Diagnostic Evaluation of MM
12. Waldenström macroglobulinemia
13. · Diagnosis and Clinical Manifestations
14. AL Amyloidosis (Light Chains)
15. · Pathophysiology of Amyloid Deposit
16. POEMS syndrome
17. · Diagnostic Criteria and Manifestations
18. Solitary Plasmocytoma
19. · Types and Diagnostic Criteria
20. Therapeutic Principles
21. · Drug Classes and Mechanisms of Action
22. Comparative Table of Entities