Hemostasis and Coagulation Disorders

Hemostasis and Coagulation Disorders — Internal Medicine

How it begins

Comprehensive analysis of the physiology of hemostasis, the differential diagnosis of hemorrhagic and thrombotic diatheses, and the advanced clinical management of each entity based on contemporary evidence.

What it covers

1. Hemostasis and Coagulation Disorders
2. Physiology of Hemostasis — The Three-Phase System
3. · Primary hemostasis — Platelet plug formation
4. The Coagulation Cascade — Contemporary Cellular Model
5. · Cellular model of coagulation — Three phases
6. · Fibrin clot formation and consolidation
7. · Natural anticoagulants — Brake system
8. Fibrinolysis — Clot Removal System
9. Laboratory Tests of Hemostasis — Expert Interpretation
10. · Front-line tests
11. · Interpretation of laboratory patterns
12. Immune Thrombocytopenic Purpura (ITP)
13. · Temporal classification
14. · Treatment by lines — ASH Guidelines 2019
15. Heparin-Induced Thrombocytopenia (HIT)
16. · Score 4T — Pretest probability of HIT
17. Thrombotic Thrombocytopenic Purpura (TTP) and Hemolytic Uremic Syndrome (HUS)
18. Other Clinically Relevant Thrombocytopenias
19. Qualitative Platelet Disorders — Bernard-Soulier and Glanzmann
20. Von Willebrand Disease (VWD) — The Most Common Coagulopathy
21. Hemophilia A and B — X-Linked Coagulopathies
22. · Clinical manifestations
23. · Treatment — Era of extended half-life (EHL) agents
24. Other Rare Hereditary Coagulopathies
25. Disseminated Intravascular Coagulation (DIC)
26. · Main causes of DIC
27. · DIC diagnostic score (ISTH 2001) — for overt DIC
28. Hepatic Coagulopathy — The Hemostatic Rebalance Paradigm
29. Management of Anticoagulant-Related Bleeding
30. Hereditary Thrombophilias — Epidemiology and Clinical Risk
31. Antiphospholipid Syndrome (APS) — Prototypical Acquired Thrombophilia
32. · Sapporo classification criteria (revised 2006)
33. · Catastrophic SAF (CAPS) — The emergency of the SAF
34. Venous Thromboembolism (VTE) — Diagnosis and Treatment
35. · Wells Score for DVT and PE — Pretest Probability
36. · Severity stratification of PE — ESC 2019 Model
37. · Duration of anticoagulation in VTE