Clinical Nutrition: Fundamentals of Nutrition and Metabolism — Expert Level Academic Guide

Clinical Nutrition · Clinical Specialties

How it begins

A comprehensive analysis of molecular mechanisms, signal transduction pathways, advanced metabolic biochemistry and clinical decision making applied to nutritional therapy in critical and chronic patients.

What it covers

1. Physiology and Metabolism
2. Physiology of Macronutrient Digestion and Absorption
3. · Enzymatic Digestion and Hydrolysis of Carbohydrates
4. · Apical and Basolateral Transport Mechanisms
5. · Lipid Digestion and Absorption
6. Cellular Bioenergetics and Hormonal Regulation
7. · Mitochondrial Thermodynamics: The Electron Transport Chain (ETC)
8. · Cellular Energy Sensors: AMPK and mTOR
9. Carbohydrate Metabolism and Related Pathology
10. · Points of Allosteric and Hormonal Regulation of Glycolysis
11. · Gluconeogenesis and the Cori Cycle
12. Lipids, Lipoproteins and Pathophysiology of Dyslipidemia
13. · Lipid Transport Routes
14. · Biochemistry of Atheroma Plaque Formation
15. Protein Metabolism and Urea Cycle
16. · Amino Acid Catabolism and Transamination
17. · The Urea Cycle (Krebs-Henseleit Cycle)
18. Water-soluble Micronutrients
19. Fat-soluble Micronutrients
20. · Calcium Homeostasis and Hormonal Mechanism of Vitamin D
21. · Vitamin K Cycle and Carboxylation Dependent Coagulation Factors
22. Trace Elements and Essential Minerals
23. · Iron Metabolism and Cellular Homeostasis
24. Regulation of Intake, Energy Expenditure and Balance
25. · Hypothalamic Axis of Intake Regulation
26. · Components of Total Energy Expenditure (GET)
27. · Measurement of Energy Expenditure: Indirect Calorimetry
28. Pathophysiology of Hospital Malnutrition
29. · Physiology of Metabolic Adaptation to Simple Fasting (Uncomplicated Starvation)
30. · Physiopathological Differences: Marasmus versus Kwashiorkor
31. Refeeding Syndrome
32. · Pathophysiology of Electrolyte Collapse
33. · Clinical Manifestations of Established Refeeding Syndrome
34. Enteral Nutritional Support
35. · Physiological Advantages of Enteral Nutrition over Parenteral Nutrition
36. · Selection of Enteral Access Routes
37. · Types of Enteral Nutrition Formulas
38. Parenteral Nutritional Support (PN)
39. · Absolute Indications for Parenteral Nutrition
40. · The Critical Osmolarity Barrier: Peripheral NP versus Central NP
41. · Evolution of Parenteral Lipid Emulsions
42. Immunonutrition and Metabolic Responses in the Critically Ill Patient
43. · Phases of the Metabolic Stress Response: The Cuthbertson Model
44. · Biological Foundations of Immunonutrients