Treatise on Prostate Pathology and Surgery — Specialization in Urology

Surgery · Clinical Specialties

How it begins

An exhaustive compendium of high surgical specialization for the modern urologist. It addresses with maximum rigor the McNeal zone anatomy, the cellular pathophysiology of hyperplasia and carcinogenesis, staging by multiparametric resonance and PET-PSMA, as well as the detailed step-by-step description of robotic-assisted radical prostatectomy (RARP), laser enucleation techniques (HoLEP) and therapies...

What it covers

1. McNeal Zonal Segmentation and Functional Histology
2. Vascularization, Aponeurotic Compartments and Cavernous Nerves
3. · Prostatic Vascularization: Pedicles and Fine Irrigation
4. · Fascial Planes of the Male Pelvis
5. Cellular, Hormonal and Stromal Physiopathology of BPH
6. · The Androgenic Pathway and the Role of Dihydrotestosterone (DHT)
7. · The Reciprocal Stroma-Epithelium Interaction and Growth Factors
8. Lower Urinary Tract Symptoms (LUTS/LUTS) and Diagnosis
9. · Physiopathology of Obstruction: Static Component vs. Dynamic
10. · Objective Diagnostic Strategies
11. Adjuvant Pharmacotherapy of BPH: Mechanisms and Clinical Trials
12. · 1. Alpha-1 Adrenergic Receptor Blockers (-blockers)
13. · 2. 5-alpha-reductase Enzyme Inhibitors (5ARIs)
14. · 3. High Evidence Combination Therapy (-blocker + 5ARI)
15. Transurethral Resection of the Prostate (TURP) Monopolar and Bipolar
16. · Technical Differences: Monopolar TURP vs. Bipolar
17. Open Prostatic Adenomectomy: Freyer and Millin Techniques
18. · 1. Transvesical Adenomectomy (Freyer Technique)
19. · 2. Extravesical Retropubic Adenomectomy (Millin Technique)
20. Laser Prostatic Enucleation: HoLEP and ThuLEP
21. · Biophysics of Laser Systems
22. · HoLEP Surgical Technique (Holmium Laser Enucleation of the Prostate)
23. New Minimally Invasive Technologies (MIST): Rezūm, Aquablation and Urolift
24. · 1. Thermal Therapy with Water Vapor (Rezūm)
25. · 2. Robotic Hydroablation by Water Jet (Aquablation)
26. · 3. Tensile Intraprostatic Staples (Urolift)
27. Molecular Biology of Carcinogenesis and PSA Controversies
28. · Molecular Basis of Prostatic Oncogenesis
29. · Fine Kinetics and Clinical Limitations of Prostate Specific Antigen (PSA)
30. Gleason and ISUP Histological Staging, and Fusion Biopsy
31. · The Gleason and ISUP Grading System
32. · MRI-Ultrasound Fusion Biopsy
33. Advanced Staging: mpMRI (PI-RADS v2.1) and PSMA Tomography
34. · Multiparametric Magnetic Resonance (mpMRI) of the Prostate
35. · Positron Emission Tomography (PET/CT) directed against PSMA
36. Robot-Assisted Radical Prostatectomy: Step-by-Step Technique
37. · Arrangement of Access Ports and Patient Positioning
38. · RARP Surgical Technique Step by Step
39. Continence Preservation Techniques and Van Velthoven Anastomosis
40. · 1. Posterior Reconstruction of the Sphincter (Rocco's Point)
41. · 2. Watertight Urethrovesical Anastomosis (Van Velthoven Technique)
42. Extended Pelvic Lymphadenectomy vs. Limited
43. · Anatomical Differences: Limited Lymphadenectomy vs. Extended
44. Management of Biochemical Recurrence and Salvage Therapies
45. · Definition of Biochemical Recurrence (BCR)
46. · Differential Diagnosis: Local Recurrence vs. Systemic (Metastatic)
47. Prostatitis and Chronic Pelvic Pain Syndrome
48. · NIH Classification of Prostatitis Syndromes
49. Clinical Management Protocols and Surgical Decision Making
50. · BPH Treatment Selection Algorithm (Based on Patient Size and Desire)