Clinical Biochemistry — Iron Metabolism

Biochemistry · Basic Sciences

How it begins

A comprehensive molecular analysis of iron balance. From the chemical coordination of the d orbitals of ferrous and ferric ions, through the mechanisms of enterocyte absorption, the plasmatic transport complex mediated by transferrin, to the exquisite systemic hormonal regulation exerted by hepcidin and the intracellular feedback controlled by the IRE/IRP system.

What it covers

1. Physicochemistry of Iron and Cellular Toxicity
2. · The Haber-Weiss and Fenton Reactions
3. · Body Iron Distribution
4. Iron Absorption and Enterocyte Physiology
5. · The Absorption Process of Non-Heme Iron
6. Plasma Transport and Cellular Uptake
7. · The Transferrin Coordinated Union
8. · The Transferrin Receptor 1 (TfR1) Endocytosis Cycle
9. Cellular Iron Storage: Ferritin and Hemosiderin
10. · Quaternary Structure and Subunits of Ferritin
11. · Hemosiderin: Insoluble Deposit
12. · Iron Release: The Mechanism of Ferritinophagy mediated by NCOA4
13. The Role of Macrophages and Iron Recycling
14. · The Physiological Mechanism of Erythrophagocytosis
15. Systemic Regulation by Hepcidin and the Inflammatory Axis
16. · The Mechanism of Cellular Action of Hepcidin
17. · Hepcidin Transcriptional Signaling Pathways (HAMP)
18. · Suppression of Hepcidin due to Erythroid Demand: Erythroferrone (ERFE)
19. Intracellular Regulation: The IRE/IRP System
20. · Iron Response Elements (IRE)
21. · The Behavior of IRP1 and IRP2 according to the Iron Status
22. Biochemistry of the Hemo Group and its Coordination
23. · The Metabolic Route of Heme Synthesis
24. Laboratory Methods and Advanced Clinical Diagnosis
25. · Iron Profile Parameters and Biochemical Interpretation
26. · Quantification of Iron Overload by Liver MRI (T2*)
27. Clinical Correlation: Iron Deficiency Anemia
28. · Pathophysiological Evolution of Iron Deficiency
29. Clinical Correlation: Anemia of Chronic Disorders
30. · Physiopathological Mechanism of Molecular Iron Sequestration
31. · Differential Diagnostic Algorithm: Pure iron deficiency vs. Anemia of Chronic Disorders
32. Clinical Correlation: Hereditary Hemochromatosis
33. · Genetic Classification of Hereditary Hemochromatosis
34. · The Classical Clinical Pentad of Organ Damage
35. Secondary Iron Overload and Marrow Insufficiency
36. · The Pathophysiology of Transfusional Iron Load
37. · Mechanism of Action of Iron Chelating Drugs
38. Ferroptosis: Iron-Dependent Regulated Cell Death
39. · Biochemical Mechanisms of Ferroptosis Induction
40. · Clinical Correlations and Pathological Implication of Ferroptosis